Toxicology Services

During the drug discovery process, preclinical/nonclinical toxicology studies are conducted to reveal a candidate molecule’s earliest potential toxic effects as it progresses from hit to lead and ultimately to a drug candidate, reducing the number of animals involved at later stages of drug discovery. Our skilled research team tailors the toxicity study protocol to meet the unique requirements of our clients. Bienta adheres to the OECD Guidelines for the Testing of Chemicals and FELASA recommendations for working with animals, and our Institutional Animal Care and Use Committee (IACUC) approves our protocols. 

Our toxicology services:

Administration routes:

  • PO, IV, IP, SC, IM, IN, with food.

We perform:

  • Observation for mortality,  signs of toxicity, and behavioral changes at all required time points after administration;
  • Weight measurement;
  • Food and water intake measurements;
  • Gross necropsy with macroscopic inspection;
  • Clinical Chemistry panel: Alkaline Phosphatase, Alanine Aminotransferase, Aspartate Aminotransferase, γ-Glutamyltransferase, Urea, Cholesterol, Creatinine, Creatine Kinase, Total Protein, Triglycerides, Lactate dehydrogenase, Total and direct bilirubin, High-density lipoproteins, and other custom parameters;
  • Hematological panel: Leukocytes (MID, Lymphocytes, Granulocytes), Erythrocytes, Platelets, Hemoglobin, Hematocrit, etc (17 parameters).
  • Histopathological assessment: all the tissues included xenografted tumors (H&E staining, immunohistochemistry, other stainings on custom request both for FFPE and cryo-sections), morphometry on the custom request. Microphotographs are provided. 

We provide all requested biological samples from experimental animals, such as plasma samples, flash-frozen tissues, paraffin- or cryogel-embedded tissues for histology, etc.

For more information, please contact us