Publications

  1. 2-Oxabicyclo[2.1.1]hexanes assaturated bioisosteres of the ortho-substituted phenyl ring. Aleksandr Denisenko, Pavel Garbuz, Nataliya M. Voloshchuk, Yuliia Holota, Galeb Al-Maali, Petro Borysko & Pavel K. Mykhailiuk; Nat. Chem, 2023,  https://doi.org/10.1038/s41557-023-01222-0
  2. Magnet for the Needle in Haystack: “Crystal Structure First” Fragment Hits Unlock Active Chemical Matter Using Targeted Exploration of Vast Chemical Spaces. Janis Müller, Raphael Klein, Olga Tarkhanova, Anastasiia Gryniukova, Petro Borysko, Stefan Merkl, Moritz Ruf, Alexander Neumann, Marcus Gastreich, Yurii S. Moroz, Gerhard Klebe, and Serghei Glinca; J. Med. Chem., September 7, 2022, https://doi.org/10.1021/acs.jmedchem.2c00813

  3. In Vitro Evaluation of In Silico Screening Approaches in Search for Selective ACE2 Binding Chemical Probes. Alexey V. Rayevsky, Andrii S. Poturai, Iryna O. Kravets, Alexander E. Pashenko, Tatiana A. Borisova, Ganna M. Tolstanova, Dmitriy M. Volochnyuk, Petro O. Borysko, Olga B. Vadzyuk, Diana O. Alieksieieva, Yuliana Zabolotna, Olga Klimchuk, Dragos Horvath, Gilles Marcou, Sergey V. Ryabukhin, Alexandre Varnek. Molecules 2022, 27(17), 5400; https://doi.org/10.3390/molecules27175400

  4. Towards in vivo photomediated delivery of anticancer peptides: Insights from pharmacokinetic and -dynamic data. Igor. Komarov, Ganna Tolstanova, Halyna Kuznietsova, Natalia Dziubenko, Petro I.Yanchuk, Lydia Y.Shtanova, Stanislav P. Veselsky Liudmyla V.Garmanchuk, Nataliia Khranovska, Oleksandr Gorbach, Taisa Dovbynchuk, Petro Borysko, Oleg Babii, Tim Schober, Anne S.Ulrich, Sergii Afonin. Journal of Photochemistry and Photobiology B: Biology, Volume 233, August 2022, 112479.

  5. Effect of gem-difluorination on the key physicochemical properties relevant to medicinal chemistry: the case of functionalized cycloalkanes. Sergey Holovach,Kostiantyn P. Melnykov,Artem Skreminskiy,Maksym Herasymchuk,Olha Tavlui,Danylo Aloshyn,Petro Borysko,Alexander B. Rozhenko,Sergey V. Ryabukhin,Dmitriy M. Volochnyuk,Oleksandr O Grygorenko. Chemistry—A European Journal, Volume 28, Issue 19 April 1, 2022 e202200331.

  6. Oxa-spirocycles: synthesis, properties and applications. Kateryna Fominova, Taras Diachuk, Dmitry Granat, Taras Savchuk, Vladyslav Vilchynskyi, Oleksiy Svitlychnyi, Vladyslav Meliantsev, Igor Kovalchuk, Eduard Litskan, Vadym V. Levterov, Valentyn R. Badlo, Ruslan I. Vaskevych, Alla I. Vaskevych, Andrii V. Bolbut, Volodymyr V. Semeno, Rustam Iminov, Kostiantyn Shvydenko, Anastasiia S. Kuznetsova, Yurii V. Dmytriv, Daniil Vysochyn, Vasyl Ripenko, Andrei A. Tolmachev, Olexandra Pavlova, Halyna Kuznietsova, Iryna Pishel, Petro Borysko and Pavel K. Mykhailiuk. Chem. Sci., 2021, 12, 11294-11305

  7. Phosphine Oxides (−POMe2) for Medicinal Chemistry: Synthesis, Properties, and Applications. Maksym V. Stambirskyi, Tetiana Kostiuk, Serhii I. Sirobaba, Alexander Rudnichenko, Dmytro L. Titikaiev, Yurii V. Dmytriv, Halyna Kuznietsova, Iryna Pishel, Petro Borysko, and Pavel K. Mykhailiuk*. Org. Chem. 2021, 86, 18, 12783–12801

  8. Screening of benzenesulfonamide in combination with chemically diverse fragments against carbonic anhydrase by differential scanning fluorimetry. M. Krasavin, S. Kalinin, S. Zozulya, A. Gryniukova, P. Borysko, A.  Angeli, C. Supuran., J. Enzym. Inhib. Med. Ch., 2020, 35 (1), pp. 306-310.

  9. Further validation of strecker-type α-aminonitriles as a new class of potent human carbonic anhydrase II inhibitors: hit expansion within the public domain using differential scanning fluorimetry leads to chemotype refinement Mikhail Krasavin, Stanislav Kalinin, Sergey Zozulya, Anastasia Griniukova, Petro Borysko, Andrea Angeli & Claudiu T. Supuran Journal of Enzyme Inhibition and Medicinal Chemistry 2020, 35:1, 165-171, doi: 10.1080/14756366.2019.1693556

  10. Oxa-spirocycles: synthesis, properties and applications. Kateryna Fominova, Taras Diachuk, Dmitry Granat, Taras Savchuk, Vladyslav Vilchynskyi, Oleksiy Svitlychnyi, Vladyslav Meliantsev, Igor Kovalchuk, Eduard Litskan, Vadym V. Levterov, Valentyn R. Badlo, Ruslan I. Vaskevych, Alla I. Vaskevych, Andrii V. Bolbut, Volodymyr V. Semeno, Rustam Iminov, Kostiantyn Shvydenko, Anastasiia S. Kuznetsova, Yurii V. Dmytriv, Daniil Vysochyn, Vasyl Ripenko, Andrei A. Tolmachev, Olexandra Pavlova, Halyna Kuznietsova, Iryna Pishel, Petro Borysko and Pavel K. Mykhailiuk. Chem. Sci., 2021, 12, 11294-11305
  11. SYNTHESIS, PHYSICO-CHEMICAL PROPERTIES AND MICROSOMAL STABILITY OF COMPOUNDS BEARING ALIPHATIC TRIFLUOROMETHOXY GROUP. Logvinenko I.; Markushyna Y.; Kondratov I.; Vashchenko B.; Kliachyna M.; Tokaryeva Y.; Pivnytska V.; Grygorenko O.; Haufe G. J. Fluorine Chem. 2020, 231, 109461 DOI: 10.1016/j.jfluchem.2020.109461
  12. Photochemical In-Flow Synthesis of 2,4-Methanopyrrolidines: Pyrrolidine Analogues with Improved Water Solubility and Reduced Lipophilicity . V.V.Levterov, O.Michurin, P.O.Borysko, S.Zozulya, I.V.Sadkova, A.A.Tolmachev, and P.K.Mykhailiuk. J. Org. Chem., 2018, 83 (23), pp 14350–14361.
  13. (Chlorosulfonyl)benzenesulfonyl Fluorides—Versatile Building Blocks for Combinatorial Chemistry: Design, Synthesis and Evaluation of a Covalent Inhibitor Library Kateryna A. Tolmachova, Yurii S. Moroz, Angelika Konovets, Maxim O. Platonov, Oleksandr V. Vasylchenko, Petro Borysko, Sergey Zozulya, Anastasia Gryniukova, Andrey V. Bogolubsky, Sergey Pipko, Pavel K. Mykhailiuk, Volodymyr S. Brovarets, Oleksandr O. Grygorenko* ACS Comb. Sci. 2018, 20, 11, 672-680
  14. Synthesis of Multifunctional Spirocyclic Azetidines and Their Application in Drug Discovery. A.A. Kirichok, I.O. Shton, I.M.Pishel, S.A. Zozulya, P.O.Borysko, V.Kubyshkin, O.A.Zaporozhets, A.A.Tolmachev, P.K. Mykhailiuk. Chem. Eu.J. 24(21), 2018, 5444-5449.
  15. Photochemical Synthesis of 2-Azabicyclo[3.2.0]heptanes: Advanced Building Blocks for Drug Discovery. Synthesis of 2,3-Ethanoproline. T.Druzhenko, Ye.Skalenko, M.Samoilenko, A.Denisenko, S.Zozulya, P.O. Borysko, M.I. Sokolenko, A.Tarasov, and P.K. Mykhailiuk. J. Org. Chem., 2018, 83 (3), pp 1394–1401.
  16. Difluoromethyl nitril oxide (CF2HCNO): overseen chemical reagent. Andrii Khutorianskyi, Bohdan Chalyk, Petro Borysko, Anna Kondratiuk, Pavel K. Mykhailiuk. EurJOC (2017); Vol. 2017(27): 3935–3940
  17. Phosphine Oxides (−POMe2) for Medicinal Chemistry: Synthesis, Properties, and Applications. Maksym V. Stambirskyi, Tetiana Kostiuk, Serhii I. Sirobaba, Alexander Rudnichenko, Dmytro L. Titikaiev, Yurii V. Dmytriv, Halyna Kuznietsova, Iryna Pishel, Petro Borysko, and Pavel K. Mykhailiuk*. Org. Chem. 2021, 86, 18, 12783–12801
  18. Screening of benzenesulfonamide in combination with chemically diverse fragments against carbonic anhydrase by differential scanning fluorimetry. M. Krasavin, S. Kalinin, S. Zozulya, A. Gryniukova, P. Borysko, A.  Angeli, C. Supuran., J. Enzym. Inhib. Med. Ch., 2020, 35 (1), pp. 306-310.
  19. Further validation of strecker-type α-aminonitriles as a new class of potent human carbonic anhydrase II inhibitors: hit expansion within the public domain using differential scanning fluorimetry leads to chemotype refinement. M. Krasavin, S. Kalinin, S. Zozulya, A. Griniukova, P. Borysko, A. Angeli, C. Supuran. J. Enzym. Inhib. Med. Ch., 2020, 35 (1), pp. 165-171.
  20. A prospective compound screening contest identified broader inhibitors for Sirtuin 1. Chiba, M. Ohue, A. Gryniukova, P. Borysko, S. Zozulya, N. Yasuo et.al. Scientific Reports, 2019, 9 (1), pp. 1-12.
  21. Pros and cons of virtual screening based on public “Big Data”: In silico mining for new bromodomain inhibitors. Iu. Casciuc, D. Horvath, A. Gryniukova, K. Tolmachova, O. Vasylchenko, P. Borysko, Yu. Moroz, Jü. Bajorath, A. Varnek. Eur. J. Med. Chem., 2019, 165, pp. 258-272.
  22. Cover Feature: Synthesis of Multifunctional Spirocyclic Azetidines and Their Application in Drug Discovery.  A.  Kirichok, I. Shton, I. Pishel, S. Zozulya, P. Borysko, V. Kubyshkin et.al., Chem. Eur. J., 2018, 24 (21), pp. 5398-5398.
  23. Photochemical Synthesis of 2-Azabicyclo[3.2.0]heptanes: Advanced Building Blocks for Drug Discovery. Synthesis of 2,3-Ethanoproline. T.Druzhenko, Ye.Skalenko, M.Samoilenko, A.Denisenko, S.Zozulya, P.O. Borysko, M.I. Sokolenko, A.Tarasov, and P.K. Mykhailiuk. J. Org. Chem., 2018, 83 (3), pp 1394–1401.
  24. Synthesis of Multifunctional Spirocyclic Azetidines and Their Application in Drug Discovery. A.A. Kirichok, I.O. Shton, I.M.Pishel, S.A. Zozulya, P.O.Borysko, V.Kubyshkin, O.A.Zaporozhets, A.A.Tolmachev, P.K. Mykhailiuk. Chem. Eu.J. 24(21), 2018, 5444-5449.
  25. Photochemical In-Flow Synthesis of 2,4-Methanopyrrolidines: Pyrrolidine Analogues with Improved Water Solubility and Reduced Lipophilicity . V.V.Levterov, O.Michurin, P.O.Borysko, S.Zozulya, I.V.Sadkova, A.A.Tolmachev, and P.K.Mykhailiuk. J. Org. Chem., 2018, 83 (23), pp 14350–14361.
  26. Synthesis of 6‐Azaspiro[4.3]alkanes: Innovative Scaffolds for Drug Discovery. B.A.Chalyk, A.A.Isakov, M.V.Butko, K.V.Hrebeniuk, O.V.Savych, O.V.Kucher, K.S.Gavrilenko, T.V.Druzhenko, V.S.Yarmolchuk, S.Zozulya, P.K.Mykhailiuk. Eur.J.Org.Chem. 2017 (31), 4530-4542.
  27. Continued SAR exploration of 1, 2, 4-thiadiazole-containing scaffolds in the design of free fatty acid receptor 1 (GPR40) agonists. M. Krasavin, A. Lukin, A. Bakholdina, N. Zhurilo, O. Onopchenko, P. Borysko et.al. Eur. J. Med. Chem., 2017, 140, pp. 229-238.
  28. An iterative compound screening contest method for identifying target protein inhibitors using the tyrosine-protein kinase Yes. Sh. Chiba, T. Ishida, […] S. Zozulya, P. Borysko, R. Stavniichuk, […], M. Sekijima. Sci Rep. 2017, 7(1), 12038.
  29. Synthesis and physical chemical properties of 2-amino-4-(trifluoromethoxy)butanoic acid – a CF3O-containing analogue of natural lipophilic amino acids I. S. Kondratov, I. G. Logvinenko, N. A. Tolmachova, R. N. Moriev, M. A. Kliachyna, F. Clausen, C. G. Daniliucc, G. Haufe Org & Biomol. Chem. 2017, V3.
  30. Photochemical Synthesis of 3-Azabicyclo[3.2.0]heptanes: Advanced Building Blocks for Drug Discovery. A.V. Denisenko, T. Druzhenko, Y.Skalenko, M. Samoilenko, O. O. Grygorenko, S. Zozulya, P. K. Mykhailiuk. J. Org. Chem. 2017, 82 (18), 9627–9636.
  31. Polar aromatic periphery increases agonist potency of spirocyclic free fatty acid receptor (GPR40) agonists inspired by LY2881835. M. Krasavin, A. Lukin, D. Bagnyukova, N. Zhurilo, A. Golovanov, S. Zozulya, I. Zahanich, D. Moore, I. G.Tikhonova. Eur.J. Med. Chem. 2017, V 127, 357-368.
  32. Novel FFA1 (GPR40) agonists containing spirocyclic periphery: polar azine periphery as a driver of potency. M. Krasavin, A. Lukin, D. Bagnyukova, N. Zhurilo, I. Zahanich, S. Zozulya. J. Enz Inhib Med Chem. 2017, V 32(1), 29-36.
  33. 1-Substituted 2-Azaspiro[3.3]heptanes: Overlooked Motifs for Drug Discovery. A. A. Kirichok, I. Shton, M. Kliachyna, I. Pishel, P. K. Mykhailiuk.  Angew. Chem. Int. Ed. Engl. 2017, 56(30), 8865-8869.
  34. Free fatty acid receptor 1 (GPR40) agonists containing spirocyclic periphery inspired by LY2881835. M. Krasavin, A. Lukin, D. Bagnyukova, N. Zhurilo, I. Zahanich, S. Zozulya, J. Ihalainen, M. M. Forsberg, M. Lehtonen, J. Rautio, D. Moore, I. G. Tikhonova. Bioorg Med Chem. 2016, V. 24 (21), 5481-5494.
  35. Direct Photocontrol of Peptidomimetics: An Alternative to Oxygen-Dependent Photodynamic Cancer Therapy. O. Babii, S. Afonin,  L.V. Garmanchuk , V.V. Nikulina, T.V. Nikolaienko, O. V. Storozhuk, D. V.Shelest, O.I. Dasyukevich, L.I.Ostapchenko, V. Iurchenko, S. Zozulya, A.S. Ulrich,  I. V. Komarov. Angew. Chem. Int. Ed. Engl. 2016, 55(18), 5493-6.
  36. Discovery of Strecker-type α-aminonitriles as a new class ofhuman carbonic anhydrase inhibitors using differential scanning fluorimetry. M. Krasavin, R. Stavniichuk, S. Zozulya, P. Borysko, D. Vullo, C. T. Supuran. J. of Enz Inhib Med Chem. 2016, 31:6, 1707-1711.
  37. Novel agonists of free fatty acid receptor 1 (GPR40) based on 3-(1,3,4-thiadiazol-2-yl)propanoic acid scaffold. M. Krasavin, A. Lukin, N. Zhurilo, A. Kovalenko, I. Zahanich, S. Zozulya. J. Enz Inhib Med Chem. 2016, 31(6), 1404-10. 
  38. Novel free fatty acid receptor 1 (GPR40) agonists based on 1,3,4-thiadiazole-2-carboxamide scaffold. M. Krasavin, A. Lukin, N. Zhurilo,
    A. Kovalenko, I. Zahanich, S. Zozulya, D. Moore, I. G. Tikhonova. Bioorg & Med Chem. 2016, V 24, 2954–63
  39. Phenoxymethyl 1,3-oxazoles and 1,2,4-oxadiazoles as potent and selective agonists of free fatty acid receptor 1 (GPR40). I. Zahanich,
    I. Kondratov, V. Naumchyk, Y. Kheylik, M. Platonov, S. Zozulya and M. Krasavin. Bioorg Med Chem Lett. 2015, V. 25(16), 3105-11.
  40. Design, synthesis, and characterization of SO2-containing azabicyclo[3.n.1]alkanes: promising building blocks for drug discovery.
    T. Druzhenko, O. Denisenko, Y. Kheylik, S. Zozulya, SS. Shishkina, A. Tolmachev and PK. Mykhailiuk. Org Lett. 2015, V. 17(8), 1922-5.
  41. Synthesis and physicochemical properties of 3-fluorocyclobutylamines. A.V. Chernykh, D.S. Radchenko, A.V. Chernykh, I.S. Kondratov, N.A. Tolmachova, O.P. Datsenko, M.A. Kurkunov, S.A. Zozulya, Y.P. Kheylik, K. Bartels, C.G. Daniliuc and G. Haufe. Eur. J. Org. Chem. 2015, V. 2015 (29), 6466–6471
  42. Role of protein phosphatase 1 in dephosphorylation of Ebola virus VP30 protein and its targeting for the inhibition of viral transcription.
    P.A. Ilinykh, B. Tigabu, A. Ivanov, T. Ammosova, Y. Obukhov, T. Garron,
    N. Kumari, D. Kovalskyy, M.O. Platonov, V.S. Naumchik, A.N. Freiberg, S. Nekhai and A. Bukreyev. J. Biol. Chem. 2014, 289, 22723-22738
  43. Potent, orally available, selective COX-2 inhibitors based on 2-imidazoline core. P. Sarnpitak, P. Mujumdar, Ch. Morisseau, S.H. Hwang,
    B. Hammock, V. Iurchenko, S. Zozulya, A. Gavalas, A. Geronikaki, Y. Ivanenkov and M. Krasavin. Eur. J. Med. Chem. 2014, V. 84, 160-172
  44. 1-Amino-4,4-difluorocyclohexanecarboxylic acid as a promising building block for drug discovery: design, synthesis and characterization. P.K. Mykhailiuk, V. Starova, V. Iurchenko, S.V. Shishkina, O.V. Shishkin,
    O. Khilchevskyi and O. Zaporozhets. Tetrahedron. 2013, V. 69 (20), 4066-4075
  45. Synthesis of 2- and 3-trifluoromethylmorpholines: useful building blocks for drug discovery. A.V. Shcherbatiuk, O.S. Shyshlyk, D.V. Yarmoliuk,
    O.V. Shishkin, S.V. Shishkina, V.S. Starova, O.A. Zaporozhets, S. Zozulya,
    R. Moriev, O. Kravchuk, O. Manoilenko, A.A. Tolmachev and P.K. Mykhailiuk. Tetrahedron. 2013, V. 69 (19) 3796-3804
  46. Synthesis and characterization of β-trifluoromethyl-substituted pyrrolidines. V.S. Yarmolchuk, O.V. Shishkin, V.S. Starova, O.A. Zaporozhets,
    O. Kravchuk, S. Zozulya, I.V. Komarov and P.K. Mykhailiuk. Eur. J. Org. Chem. 2013, 15, 3086–3093
  47. Insulin receptor-related receptor as an extracellular pH sensor involved in the regulation of acid-base balance. A.G. Petrenko, S.A. Zozulya, I.E. Deyev and D. Eladari. Biochimica et Biophysica Acta. 2013; V. 1834 (10), 2170–2175
  48. Identification of novel IGF1R kinase inhibitors by molecular modeling and high-throughput screening. R. Moriev, O. Vasylchenko, M. Platonov,
    O. Grygorenko, K. Volkova and S. Zozulya. Acta naturae. 2013, V. 5 (2), 90-99
  49. Small molecules targeted to a non-catalytic “RVxF” binding site of protein phosphatase-1 inhibit HIV-1. T. Ammosova, M. Platonov,
    V.R.K. Yedavalli, Y. Obukhov, V.R. Gordeuk, K.-T. Jeang, D. Kovalskyy and
    S. Nekhai. PLOS ONE. 2012, V. 7 (6), e39481, 1-16