In order to continue expanding our services in preclinical toxicology and animal efficacy models, in 2016 Bienta launched the on-site laboratory for in vivo studies in rodents.  This new animal facility allowed us to facilitate communication between departments and researchers involved in the drug discovery process.  Our nearest plans include the development of an array of preclinical toxicology studies, including reproduction toxicology, safety pharmacology, photosafety.  We are also working on the development of animal models for biological screening of specific activity, such as rodent efficacy models for the therapeutic areas of anti-infectives, inflammation and pain.

Bienta/Enamine Animal Work Statement

Animal studies

  • Pharmacokinetic Studies in Mice and Rats
  • Acute Toxicity
  • LD50 Study
  • MTD/NOEL Study
  • Subacute, subchronic/chronic toxicity
  • Cardiac toxicity (Perfused Isolated Langerdorff Heart)
  • Animal models
    • Glucose Tolerance Test (in normal or pathologic animals)
    • Insulin Tolerance Test (in normal or pathologic animals)
    • Streptozotocin-induced Type 1 Diabetes
    • HFD/Streptozotocin-induced Type 2 Diabetes