Dose range finding (DRF)

The dose range-finding (DRF) is an initial part of the toxicity study aimed to find the dose that will produce tolerable levels of adverse toxic effects of tested compounds. We investigate the adverse effects of acute doses administration and determine the different tolerable levels of doses – usually maximum tolerated dose (MTD), the no-observed-adverse-effect level (NOAEL) – depending on the aim of the study.  Blood microsampling procedures are available to reduce the animal number. A customized DRF design is also available.

Adverse effects investigation:

  • Observations for clinical signs and mortality;
  • Gross necropsy with macroscopic inspection;
  • Customized parameters by request (blood count, clinical chemistry, metabolic values, tissue histopathology, behavioral tests, etc.) 

Deliverable: A detailed study report including the description of the study design, experimental data, and interpretation, preliminary statistics, and requested tissue samples. Raw experimental data are available upon request. 

Sample Submission. Dry compound or compound in a pre-made animal dosing formulation. The amount depends on the dosing levels. For example, 1 mg of a compound will be enough for 10 mg/kg dosing.