L-arginine (or Secretagogue (Caerulein)) acute pancreatitis models in rats. Background: L-arginine is widely used in therapy as a substrate for neuronal, inducible, and endothelial nitric […] Read More
Author: Anna Pashkova
The osteoporosis model in rats is achieved by ovariectomy procedure. Ovariectomy in adult animals induces estrogen deficiency and subsequent bone loss with corresponding clinical manifestations […] Read More
Tumor Necrosis Factor (TNF-α) is a proinflammatory cytokine with a significant ability to induce inflammation. Single parenteral administration of TNF-α is used as a model […] Read More
Animal models are essential for exploring acute renal failure (ARF) and the development of effective therapy for its optimal management. At Bienta we utilize several […] Read More
Background: Diet with increased content of salt (High Salt Diet, HSD) is widely used for accelerating some aging-associated pathology – gastritis, renal, neuronal failure, hypertension […] Read More
Spontaneously Hypertensive Rats (SHRs) is the best-investigated animal model of essential (or primary) hypertension used to study and treat cardiovascular disease. SH rats develop hypertension […] Read More
Infusion toxicology in preclinical studies are meant to asses the safety of therapeutic candidates intended for continuous administration in clinics. Slow infusions are possible through […] Read More
In vivo Mammalian Alkaline Comet Assay The test is used to detect the influence of potentially genotoxic substances in vivo under experimental conditions. Comet analysis […] Read More
Skin sensitization test in guinea pigs is a preferred method for the detection of the potential of a substance to cause allergic contact dermatitis. The […] Read More
The method is based on the assessment of the degree of eye damage after local exposure to a potential irritant. The occurrence of lesions of […] Read More