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Bienta Contract Research Services: HTS, ADME, drug metabolism, toxicity, lead optimization

  • Home
  • About Us
    • Our Mission
    • Scientific Leadership
    • Strategic Partners
    • Certificates
    • Publications
  • Resources
    • Molecular Screening (HTS) Laboratory
    • Bioanalytical Laboratory
    • in vivo Research Facility
    • New Technology Department
  • Services
    • Molecular Screening (HTS)
    • ADMET and Pharmacokinetics
    • Animal Studies
    • In silico modeling and chemoinformatics
    • Screening by MS
    • Recombinant Protein Production
  • Animal Studies
    • Formulation Screening
    • Pharmacokinetics & Pharmacodynamics
    • Toxicology Services
    • Pathology models
    • Cancer
    • Aging
    • Behavior
  • News
  • Careers
  • Photo
  • Video
  • Contact us

Author: Anna Pashkova

Без рубрики Posted on04.02.202229.03.2023

Acute pancreatitis models

L-arginine (or Secretagogue (Caerulein)) acute pancreatitis models in rats. Background: L-arginine is widely used in therapy as a substrate for neuronal, inducible, and endothelial nitric […] Read More

Без рубрики Posted on04.02.202218.04.2022

Rat Model for Osteoporosis

The osteoporosis model in rats is achieved by ovariectomy procedure.  Ovariectomy in adult animals induces estrogen deficiency and subsequent bone loss with corresponding clinical manifestations […] Read More

Pathology models Posted on04.02.202207.02.2022

Tumor Necrosis Factor induced inflammation in mice

Tumor Necrosis Factor (TNF-α) is a proinflammatory cytokine with a significant ability to induce inflammation. Single parenteral administration of TNF-α is used as a model […] Read More

Pathology models Posted on04.02.202207.07.2023

Acute kidney injury models

Animal models are essential for exploring acute renal failure (ARF) and the development of effective therapy for its optimal management. At Bienta we utilize several […] Read More

Без рубрики Posted on04.02.2022

High Salt Diet-induced pathology in mice

Background: Diet with increased content of salt (High Salt Diet, HSD) is widely used for accelerating some aging-associated pathology – gastritis, renal, neuronal failure, hypertension […] Read More

Pathology models Posted on04.02.202201.09.2023

Hypertension model in rats

Spontaneously Hypertensive Rats (SHRs) is the best-investigated animal model of essential (or primary) hypertension used to study and treat cardiovascular disease. SH rats develop hypertension […] Read More

Toxicity Studies Posted on04.02.202213.12.2022

Infusion toxicology

Infusion toxicology in preclinical studies are meant to asses the safety of therapeutic candidates intended for continuous administration in clinics. Slow infusions are possible through […] Read More

Toxicity Studies Posted on02.02.202204.02.2022

Genotoxicity assays

In vivo Mammalian Alkaline Comet Assay The test is used to detect the influence of potentially genotoxic substances in vivo under experimental conditions. Comet analysis […] Read More

Toxicity Studies Posted on02.02.2022

Skin Sensitisation Test in Guinea Pig

Skin sensitization test in guinea pigs is a preferred method for the detection of the potential of a substance to cause allergic contact dermatitis. The […] Read More

Toxicity Studies Posted on02.02.2022

In Vivo Eye Irritation Test

The method is based on the assessment of the degree of eye damage after local exposure to a potential irritant. The occurrence of lesions of […] Read More

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