Potential drug candidate development proceeds with the investigation of a variety of adverse effects including immune system failure. The service includes assessment of suppression or enhancement of the immune functions after treatment by testing the compound.
Service details: The service proposes various study designs to assess the suppression or enhancing the immune response in rodents, as a choice to develop hypersensitivity (allergic) reactions after exposures to the testing drug in guinea pigs. Standard study design in rodents includes investigation of hematological parameters, immune organ weights/cellularity (thymus, spleen, lymph nodes, bone marrow), serum immunoglobulins level. Specific immunological tests are available – antigen-specific plaque-forming cells testing, RBTL in vitro, immunophenotyping of leukocyte populations in the blood or lymphoid tissues, and other customized methods.