Metabolic Stability Assay

Background: Microsomes and hepatocytes from liver are used to study drug metabolism in vitro. Metabolic transformation of a drug taking place in liver can change significantly its efficacy and safety. For this reason drug candidates are screened early in the discovery process for metabolic stability.



Data include parent compound percent remaining, half-life and clearance values. Full study report is provided.

Sample Requirement/Submission

A minimal weighted amount of dry compound, 1 mg, or 200 µL of 10mM stock DMSO solution, is required for this assay.  For multiple assays, lesser amount of compound per assay may be sufficient, which should be discussed for each particular case.