Determining pKa


The tendency of a compound to donate a proton is expressed as its acid ionization constant (dissociation constant), or Ka, and is usually represented as pKa (pKa =  ̶  log Ka). There is a documented correlation between pKa of a drug and its solubility that is widely used for the prediction of drug behavior in vivo. pKa value may have a profound effect on pharmacological activity, bioavailability and toxicity of a drug, and therefore is a valuable readout in the selection process.



Final report comprising information on the analysis, methodology, raw data, and interpretation of the results is provided.

Sample Submission:

Approximately 40 µmol (20 mg) of dry compound is necessary for this test.