The tendency of a compound to donate a proton is expressed as its acid ionization constant (dissociation constant), or Ka, and is usually represented as pKa (pKa = ̶ log Ka). There is a documented correlation between pKa of a drug and its solubility that is widely used for the prediction of drug behavior in vivo. pKa value may have a profound effect on pharmacological activity, bioavailability and toxicity of a drug, and therefore is a valuable readout in the selection process.
Final report comprising information on the analysis, methodology, raw data, and interpretation of the results is provided.
Approximately 40 µmol (20 mg) of dry compound is necessary for this test.