New approach for solubility testing is available at Bienta LTD with the Agilent 1260 Infinity that was installed at Bioanalytical Laboratory. The Agilent 1260 Infinity with Diode Array Detector equipped with OpenLab software is designed to provide high sensitivity (noise <±3µAU), and lowest peak dispersion for 2.1, 3 and 4.6 mm ID columns. Wide linear range (typically up to 2.5 AU) gives an advantage for reliable, simultaneous quantification of primary compounds, by-products and impurities. This detector has great advantage if compare to MS/MS technique. It can detect spectra of non-ionizible compounds.
absorption acute ADME assay binding biochemical bioequivalence channel cytotoxicity DELFIA development distribution diversity Enamine excretion FLIPR FRET GPCR hERG HTRF HTS ion kinase LANCE LC/MS ligand membrane metabolism model molecular MS/MS permeability pharmacokinetics pharmacophore plasma plate preclinical protein reader screening solubility toxicity TR-FRET triple quadrupole virtual