Bienta has recently supported molecular modeling assessment project ran at Tokyo Institute of Technology, Japan. YES tyrosine kinase targeted library created by 10 competing in silico molecular modeling teams organized by Initiative for Parallel Bioinformatics ( IPAB) was successfully screened by Bienta to identify hits. The library consisting of 600 compounds was selected from Enamine’s Screening Compounds Collection of close to 2,000,000 compounds. Bienta enjoys unlimited and immediate access to the vast Enamine compound repository, allowing prompt and efficient high-throughput screening, hit verification “from powders” and hit expansion follow-ups.
absorption acute ADME assay binding biochemical bioequivalence channel cytotoxicity DELFIA development distribution diversity Enamine excretion FLIPR FRET GPCR hERG HTRF HTS ion kinase LANCE LC/MS ligand membrane metabolism model molecular MS/MS permeability pharmacokinetics pharmacophore plasma plate preclinical protein reader screening solubility toxicity TR-FRET triple quadrupole virtual