Repeated dose toxicity study is usually conducted with the aim to determine the specific dose (MTD, or NOAEL) after repeated dosage. Treatment design and duration both depend on a therapeutic treatment schedule. The study design includes 1-3 tested doses per route in animals of both sexes, 6-10 animals per each group. On average, 30 animals and 30 working days are required for this study. A customized design is also available.
Pathology-specific side effects investigation:
– observations of clinical signs of toxicity
– clinical chemistry
– metabolic values
– customized parameters.
Deliverable: A detailed study report including full description of study design, analytical method development, calculations of all common PK parameters and PK graphs. Raw experimental data are available upon request.
Sample Submission: Dry compound or compound in a pre-made animal dosing formulation. Amounts depend on the dosing levels. For acute toxicology study in group of 30 mice at 10 mg/kg, approximately 10 mg of compound is required.