Background and Service Details

Pharmacokinetic (PK) studies could significantly vary in design depending upon their goals and parameters of the tested compounds. We offer PK in common inbred mouse lines (C57BL, FVB or BALB/C) or Wistar rats. A typical PK study in mice would involve two drug delivery routes (e.g. PO and IV), 6 time points for each route (typically 5, 15, 30, 60, 120, 240 min) and 4 animals per each time point group/route, plus the common control plasma group (”0”) – 50 animals in total. We will prepare blood plasma samples and measure compound concentrations by LC-MS/MS. We use Applied Biosystems/PE Sciex API3000 mass spectrometers and Shimadzu VP HPLCs. Analyte measurements in other tissues, measurements of various PD parameters, development of optimized drug delivery formulations as well as metabolite ID services are offered at extra charge.


A detailed study report including full description of study design, analytical method development, raw experimental data, calculations of all common PK parameters and PK graphs.

PK curve

Sample Submission

Dry compound or compound in pre-made dosing formulation. Amounts depend upon the dosing levels. For a PK study in mice at 10 mg/kg PO and 10 mg/kg IV about 16 mg of compound is required.


Bienta/Enamine Animal Work Statement