BALB/cAnN Mice Strain

 

BALB/cAnN is an inbred mice strain. Haplotype: H2 d. High breading performance. Balb/c mice are widely used for general experimental studies in toxicology, pharmacology, teratology, and parasitology. Commonly applied for more specific purpose: obtaining hybridomas and monoclonal antibodies, infectious diseases studies; hippocampus related diseases, oncology (breast cancer), and behavioral research. Due to the low level of spontaneous tumors, the strain is often used in long-term experiments, being a popular model in gene-engineering experiments. Being relatively resistant to diet-induced atherosclerosis BALB/c mice are useful model for cardiovascular research. Balb/c mice are noted for high level of anxiety. Sensitive to radiation. In later life might develop some types of cancers. This strain is sensitive to Listeriosis, all types of Leishmani and some types of Trypanosomes. Female mice have low productivity: only 47% couplings are effective.

C57Bl/6 Mice Strain 

C57Bl/6 is an inbred mice strain. Haplotype: H2 b. The coat color is black. This strain is often used as a model for diabetes, obesity, atherosclerosis. Two substrains (6J and 6N) differ on diet-induced obesity development:  6J are more susceptible. Due to their physical activity they are suitable for behavioral studies. Also they are commonly used as knockout model.  Mice C57Bl/6 do not develop breast tumor. However, particular features of these mice consist on partial abnormal development with defects of the scull, spine, limbs and eyes/vision. The strain has high productivity: from 84% to 87% couplings are effective.

 

CD-1 Mice Strain

CD-1 strain is an outbred mice with white coat color. Developed from Swiss mice at the Anti-Cancer Center in Switzerland. The strain is widely used as a cost-effective model for preliminary studies in toxicology, oncology, pharmacology, immunology, and virology. Well suited for aging research. CD-1 mice strain is suitable for behavioral research and as a surgical model. The strain has perfect breeding qualities (up to 93%) and active/agressive behavior. Typical litter size is 10-13 offspring.

 

C3H/HeOuJ Mice Strain 

C3H/HeOuJ is an inbred mice with agouti coat color. The strain was created by mating albino female with DBA male. C3H/HeOuJ mice are mainly used in immunology, parasitology, virology, oncology and immunogenetics. Also they commonly used in sensorineural and cardiovascular studies. C3H/HeOuJ mice are sensitive for the Gram-negative infection. Female mice are characterized by high level of breast tumor development. Mating productivity is very high (up to 100%), however, the litter is smaller, compared to the other strains (2-5 offspring).

 

NMRI (Han) Mice Strain 

NMRI is an outbred mice strain with white coat color.  Obtained from inbred strain NIH/P1.  The strain is commonly used as a model for toxicology, oncology, pharmacology, teratology, immunology, virology, and neurology.  Most suitable as a behavioral and surgical model. NMRI mice have age-related increase in spontaneous tumors and kidney diseases.  Very high level of productivity: 86-92%, with a litter of 10-13 offspring.