Our Mission

In 2011, Enamine announced opening of a contract research laboratory (CRO) for bioscreening and ADMET testing services at its main research site in Kiev, Ukraine.  Since June 2013, Enamine’s biological testing services are offered under a trademark of Bienta. (more…)

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Certificates

Bioanalytical Laboratory at Bienta operates according to the standard international quality control practices and has a permit from Ukrainian regulatory agencies to provide analytical support for clinical trial PK/bioequivalence studies in humans (more…)

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Publications

  1. Oxa-spirocycles: synthesis, properties and applications. Kateryna Fominova, Taras Diachuk, Dmitry Granat, Taras Savchuk, Vladyslav Vilchynskyi, Oleksiy Svitlychnyi, Vladyslav Meliantsev, Igor Kovalchuk, Eduard Litskan, Vadym V. Levterov, Valentyn R. Badlo, Ruslan I. Vaskevych, Alla I. Vaskevych, Andrii V. Bolbut, Volodymyr V. Semeno, Rustam Iminov, Kostiantyn Shvydenko, Anastasiia S. Kuznetsova, Yurii V. Dmytriv, Daniil Vysochyn, Vasyl Ripenko, Andrei A. Tolmachev, Olexandra Pavlova, Halyna Kuznietsova, Iryna Pishel, Petro Borysko and Pavel K. Mykhailiuk. Chem. Sci., 2021, 12, 11294-11305
  2. SYNTHESIS, PHYSICO-CHEMICAL PROPERTIES AND MICROSOMAL STABILITY OF COMPOUNDS BEARING ALIPHATIC TRIFLUOROMETHOXY GROUP. Logvinenko I.; Markushyna Y.; Kondratov I.; Vashchenko B.; Kliachyna M.; Tokaryeva Y.; Pivnytska V.; Grygorenko O.; Haufe G. J. Fluorine Chem. 2020, 231, 109461 DOI: 10.1016/j.jfluchem.2020.109461
  3. Photochemical In-Flow Synthesis of 2,4-Methanopyrrolidines: Pyrrolidine Analogues with Improved Water Solubility and Reduced Lipophilicity . V.V.Levterov, O.Michurin, P.O.Borysko, S.Zozulya, I.V.Sadkova, A.A.Tolmachev, and P.K.Mykhailiuk. J. Org. Chem., 2018, 83 (23), pp 14350–14361.
  4. (Chlorosulfonyl)benzenesulfonyl Fluorides—Versatile Building Blocks for Combinatorial Chemistry: Design, Synthesis and Evaluation of a Covalent Inhibitor Library Kateryna A. Tolmachova, Yurii S. Moroz, Angelika Konovets, Maxim O. Platonov, Oleksandr V. Vasylchenko, Petro Borysko, Sergey Zozulya, Anastasia Gryniukova, Andrey V. Bogolubsky, Sergey Pipko, Pavel K. Mykhailiuk, Volodymyr S. Brovarets, Oleksandr O. Grygorenko* ACS Comb. Sci. 2018, 20, 11, 672-680
  5. Synthesis of Multifunctional Spirocyclic Azetidines and Their Application in Drug Discovery. A.A. Kirichok, I.O. Shton, I.M.Pishel, S.A. Zozulya, P.O.Borysko, V.Kubyshkin, O.A.Zaporozhets, A.A.Tolmachev, P.K. Mykhailiuk. Chem. Eu.J. 24(21), 2018, 5444-5449.
  6. Photochemical Synthesis of 2-Azabicyclo[3.2.0]heptanes: Advanced Building Blocks for Drug Discovery. Synthesis of 2,3-Ethanoproline. T.Druzhenko, Ye.Skalenko, M.Samoilenko, A.Denisenko, S.Zozulya, P.O. Borysko, M.I. Sokolenko, A.Tarasov, and P.K. Mykhailiuk. J. Org. Chem., 2018, 83 (3), pp 1394–1401.
  7. Difluoromethyl nitril oxide (CF2HCNO): overseen chemical reagent. Andrii Khutorianskyi, Bohdan Chalyk, Petro Borysko, Anna Kondratiuk, Pavel K. Mykhailiuk. EurJOC (2017); Vol. 2017(27): 3935–3940
  8. Phosphine Oxides (−POMe2) for Medicinal Chemistry: Synthesis, Properties, and Applications. Maksym V. Stambirskyi, Tetiana Kostiuk, Serhii I. Sirobaba, Alexander Rudnichenko, Dmytro L. Titikaiev, Yurii V. Dmytriv, Halyna Kuznietsova, Iryna Pishel, Petro Borysko, and Pavel K. Mykhailiuk*. Org. Chem. 2021, 86, 18, 12783–12801
  9. Screening of benzenesulfonamide in combination with chemically diverse fragments against carbonic anhydrase by differential scanning fluorimetry. M. Krasavin, S. Kalinin, S. Zozulya, A. Gryniukova, P. Borysko, A.  Angeli, C. Supuran., J. Enzym. Inhib. Med. Ch., 2020, 35 (1), pp. 306-310.
  10. Further validation of strecker-type α-aminonitriles as a new class of potent human carbonic anhydrase II inhibitors: hit expansion within the public domain using differential scanning fluorimetry leads to chemotype refinement. M. Krasavin, S. Kalinin, S. Zozulya, A. Griniukova, P. Borysko, A. Angeli, C. Supuran. J. Enzym. Inhib. Med. Ch., 2020, 35 (1), pp. 165-171.
  11. A prospective compound screening contest identified broader inhibitors for Sirtuin 1. Chiba, M. Ohue, A. Gryniukova, P. Borysko, S. Zozulya, N. Yasuo et.al. Scientific Reports, 2019, 9 (1), pp. 1-12.
  12. Pros and cons of virtual screening based on public “Big Data”: In silico mining for new bromodomain inhibitors. Iu. Casciuc, D. Horvath, A. Gryniukova, K. Tolmachova, O. Vasylchenko, P. Borysko, Yu. Moroz, Jü. Bajorath, A. Varnek. Eur. J. Med. Chem., 2019, 165, pp. 258-272.
  13. Cover Feature: Synthesis of Multifunctional Spirocyclic Azetidines and Their Application in Drug Discovery.  A.  Kirichok, I. Shton, I. Pishel, S. Zozulya, P. Borysko, V. Kubyshkin et.al., Chem. Eur. J., 2018, 24 (21), pp. 5398-5398.
  14. Photochemical Synthesis of 2-Azabicyclo[3.2.0]heptanes: Advanced Building Blocks for Drug Discovery. Synthesis of 2,3-Ethanoproline. T.Druzhenko, Ye.Skalenko, M.Samoilenko, A.Denisenko, S.Zozulya, P.O. Borysko, M.I. Sokolenko, A.Tarasov, and P.K. Mykhailiuk. J. Org. Chem., 2018, 83 (3), pp 1394–1401.
  15. Synthesis of Multifunctional Spirocyclic Azetidines and Their Application in Drug Discovery. A.A. Kirichok, I.O. Shton, I.M.Pishel, S.A. Zozulya, P.O.Borysko, V.Kubyshkin, O.A.Zaporozhets, A.A.Tolmachev, P.K. Mykhailiuk. Chem. Eu.J. 24(21), 2018, 5444-5449.
  16. Photochemical In-Flow Synthesis of 2,4-Methanopyrrolidines: Pyrrolidine Analogues with Improved Water Solubility and Reduced Lipophilicity . V.V.Levterov, O.Michurin, P.O.Borysko, S.Zozulya, I.V.Sadkova, A.A.Tolmachev, and P.K.Mykhailiuk. J. Org. Chem., 2018, 83 (23), pp 14350–14361.
  17. Synthesis of 6‐Azaspiro[4.3]alkanes: Innovative Scaffolds for Drug Discovery. B.A.Chalyk, A.A.Isakov, M.V.Butko, K.V.Hrebeniuk, O.V.Savych, O.V.Kucher, K.S.Gavrilenko, T.V.Druzhenko, V.S.Yarmolchuk, S.Zozulya, P.K.Mykhailiuk. Eur.J.Org.Chem. 2017 (31), 4530-4542.
  18. Continued SAR exploration of 1, 2, 4-thiadiazole-containing scaffolds in the design of free fatty acid receptor 1 (GPR40) agonists. M. Krasavin, A. Lukin, A. Bakholdina, N. Zhurilo, O. Onopchenko, P. Borysko et.al. Eur. J. Med. Chem., 2017, 140, pp. 229-238.
  19. An iterative compound screening contest method for identifying target protein inhibitors using the tyrosine-protein kinase Yes. Sh. Chiba, T. Ishida, […] S. Zozulya, P. Borysko, R. Stavniichuk, […], M. Sekijima. Sci Rep. 2017, 7(1), 12038.
  20. Synthesis and physical chemical properties of 2-amino-4-(trifluoromethoxy)butanoic acid – a CF3O-containing analogue of natural lipophilic amino acids I. S. Kondratov, I. G. Logvinenko, N. A. Tolmachova, R. N. Moriev, M. A. Kliachyna, F. Clausen, C. G. Daniliucc, G. Haufe Org & Biomol. Chem. 2017, V3.
  21. Photochemical Synthesis of 3-Azabicyclo[3.2.0]heptanes: Advanced Building Blocks for Drug Discovery. A.V. Denisenko, T. Druzhenko, Y.Skalenko, M. Samoilenko, O. O. Grygorenko, S. Zozulya, P. K. Mykhailiuk. J. Org. Chem. 2017, 82 (18), 9627–9636.
  22. Polar aromatic periphery increases agonist potency of spirocyclic free fatty acid receptor (GPR40) agonists inspired by LY2881835. M. Krasavin, A. Lukin, D. Bagnyukova, N. Zhurilo, A. Golovanov, S. Zozulya, I. Zahanich, D. Moore, I. G.Tikhonova. Eur.J. Med. Chem. 2017, V 127, 357-368.
  23. Novel FFA1 (GPR40) agonists containing spirocyclic periphery: polar azine periphery as a driver of potency. M. Krasavin, A. Lukin, D. Bagnyukova, N. Zhurilo, I. Zahanich, S. Zozulya. J. Enz Inhib Med Chem. 2017, V 32(1), 29-36.
  24. 1-Substituted 2-Azaspiro[3.3]heptanes: Overlooked Motifs for Drug Discovery. A. A. Kirichok, I. Shton, M. Kliachyna, I. Pishel, P. K. Mykhailiuk.  Angew. Chem. Int. Ed. Engl. 2017, 56(30), 8865-8869.
  25. Free fatty acid receptor 1 (GPR40) agonists containing spirocyclic periphery inspired by LY2881835. M. Krasavin, A. Lukin, D. Bagnyukova, N. Zhurilo, I. Zahanich, S. Zozulya, J. Ihalainen, M. M. Forsberg, M. Lehtonen, J. Rautio, D. Moore, I. G. Tikhonova. Bioorg Med Chem. 2016, V. 24 (21), 5481-5494.
  26. Direct Photocontrol of Peptidomimetics: An Alternative to Oxygen-Dependent Photodynamic Cancer Therapy. O. Babii, S. Afonin,  L.V. Garmanchuk , V.V. Nikulina, T.V. Nikolaienko, O. V. Storozhuk, D. V.Shelest, O.I. Dasyukevich, L.I.Ostapchenko, V. Iurchenko, S. Zozulya, A.S. Ulrich,  I. V. Komarov. Angew. Chem. Int. Ed. Engl. 2016, 55(18), 5493-6.
  27. Discovery of Strecker-type α-aminonitriles as a new class ofhuman carbonic anhydrase inhibitors using differential scanning fluorimetry. M. Krasavin, R. Stavniichuk, S. Zozulya, P. Borysko, D. Vullo, C. T. Supuran. J. of Enz Inhib Med Chem. 2016, 31:6, 1707-1711.
  28. Novel agonists of free fatty acid receptor 1 (GPR40) based on 3-(1,3,4-thiadiazol-2-yl)propanoic acid scaffold. M. Krasavin, A. Lukin, N. Zhurilo, A. Kovalenko, I. Zahanich, S. Zozulya. J. Enz Inhib Med Chem. 2016, 31(6), 1404-10. 
  29. Novel free fatty acid receptor 1 (GPR40) agonists based on 1,3,4-thiadiazole-2-carboxamide scaffold. M. Krasavin, A. Lukin, N. Zhurilo,
    A. Kovalenko, I. Zahanich, S. Zozulya, D. Moore, I. G. Tikhonova. Bioorg & Med Chem. 2016, V 24, 2954–63
  30. Phenoxymethyl 1,3-oxazoles and 1,2,4-oxadiazoles as potent and selective agonists of free fatty acid receptor 1 (GPR40). I. Zahanich,
    I. Kondratov, V. Naumchyk, Y. Kheylik, M. Platonov, S. Zozulya and M. Krasavin. Bioorg Med Chem Lett. 2015, V. 25(16), 3105-11.
  31. Design, synthesis, and characterization of SO2-containing azabicyclo[3.n.1]alkanes: promising building blocks for drug discovery.
    T. Druzhenko, O. Denisenko, Y. Kheylik, S. Zozulya, SS. Shishkina, A. Tolmachev and PK. Mykhailiuk. Org Lett. 2015, V. 17(8), 1922-5.
  32. Synthesis and physicochemical properties of 3-fluorocyclobutylamines. A.V. Chernykh, D.S. Radchenko, A.V. Chernykh, I.S. Kondratov, N.A. Tolmachova, O.P. Datsenko, M.A. Kurkunov, S.A. Zozulya, Y.P. Kheylik, K. Bartels, C.G. Daniliuc and G. Haufe. Eur. J. Org. Chem. 2015, V. 2015 (29), 6466–6471
  33. Role of protein phosphatase 1 in dephosphorylation of Ebola virus VP30 protein and its targeting for the inhibition of viral transcription.
    P.A. Ilinykh, B. Tigabu, A. Ivanov, T. Ammosova, Y. Obukhov, T. Garron,
    N. Kumari, D. Kovalskyy, M.O. Platonov, V.S. Naumchik, A.N. Freiberg, S. Nekhai and A. Bukreyev. J. Biol. Chem. 2014, 289, 22723-22738
  34. Potent, orally available, selective COX-2 inhibitors based on 2-imidazoline core. P. Sarnpitak, P. Mujumdar, Ch. Morisseau, S.H. Hwang,
    B. Hammock, V. Iurchenko, S. Zozulya, A. Gavalas, A. Geronikaki, Y. Ivanenkov and M. Krasavin. Eur. J. Med. Chem. 2014, V. 84, 160-172
  35. 1-Amino-4,4-difluorocyclohexanecarboxylic acid as a promising building block for drug discovery: design, synthesis and characterization. P.K. Mykhailiuk, V. Starova, V. Iurchenko, S.V. Shishkina, O.V. Shishkin,
    O. Khilchevskyi and O. Zaporozhets. Tetrahedron. 2013, V. 69 (20), 4066-4075
  36. Synthesis of 2- and 3-trifluoromethylmorpholines: useful building blocks for drug discovery. A.V. Shcherbatiuk, O.S. Shyshlyk, D.V. Yarmoliuk,
    O.V. Shishkin, S.V. Shishkina, V.S. Starova, O.A. Zaporozhets, S. Zozulya,
    R. Moriev, O. Kravchuk, O. Manoilenko, A.A. Tolmachev and P.K. Mykhailiuk. Tetrahedron. 2013, V. 69 (19) 3796-3804
  37. Synthesis and characterization of β-trifluoromethyl-substituted pyrrolidines. V.S. Yarmolchuk, O.V. Shishkin, V.S. Starova, O.A. Zaporozhets,
    O. Kravchuk, S. Zozulya, I.V. Komarov and P.K. Mykhailiuk. Eur. J. Org. Chem. 2013, 15, 3086–3093
  38. Insulin receptor-related receptor as an extracellular pH sensor involved in the regulation of acid-base balance. A.G. Petrenko, S.A. Zozulya, I.E. Deyev and D. Eladari. Biochimica et Biophysica Acta. 2013; V. 1834 (10), 2170–2175
  39. Identification of novel IGF1R kinase inhibitors by molecular modeling and high-throughput screening. R. Moriev, O. Vasylchenko, M. Platonov,
    O. Grygorenko, K. Volkova and S. Zozulya. Acta naturae. 2013, V. 5 (2), 90-99
  40. Small molecules targeted to a non-catalytic “RVxF” binding site of protein phosphatase-1 inhibit HIV-1. T. Ammosova, M. Platonov,
    V.R.K. Yedavalli, Y. Obukhov, V.R. Gordeuk, K.-T. Jeang, D. Kovalskyy and
    S. Nekhai. PLOS ONE. 2012, V. 7 (6), e39481, 1-16

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