Researchers from Bienta/Enamine presented a poster during MIPTEC exhibition’2017 in Basel, Switzerland: “Reduced cardiotoxicity of spiro-tetrahydropyran bupivacaine analogues”. The goal of this study was to create active structural analogs of bupivacaine with reduced general and cardiotoxicity due to in silico modifications designed to affect their interaction with Nav1.5 channel, which is believed to be the main target of bupivacaine toxicity.

Poster Basel 2017